September 26, 2014

Cytonome demonstrates rapid and sterile regulatory T cell purification

Boston, MA

Regulatory T cell

Regulatory T Cell

Cytonome demonstrates rapid and sterile regulatory T cell purification

Cytonome, a developer and manufacturer of advanced cell purification systems, today announced a milestone in the rapid, sterile purification of regulatory T cells. The study, published online in the journal Cytotherapy, describes the use of the Gigasort™ cell purification system to isolate regulatory T cells from a sample of mononuclear cells. Regulatory T cells are currently being tested in clinical trials for the treatment of autoimmune diseases (such as diabetes), graft-versus-host disease, and transplant rejection. Purifying viable regulatory T cells in a clinical setting has been a major challenge, due to the rarity of these cells and the need to purify them in a sterile environment.

In this study, Cytonome researchers were able to purify up to 1.7 million viable regulatory T cells from 450 million fresh peripheral blood mononuclear cells in under 4 hours using the Gigasort™ cell purification system. Cytonome’s Gigasort™ system uses parallel sorting technology coupled with a closed, sterile disposable cartridge to provide increased throughput, safety and sterility in applications such as regulatory T cell production.

“Sterile purification of regulatory T cells is an extremely important step if we wish to use these cells in a clinical setting to help organ transplantation patients. In our study, Cytonome’s Gigasort™ system was able to produce a clinically-relevant number of sterile and pure regulatory T cells with excellent viability. This study demonstrates the feasibility of using this technology in future clinical transplantation studies.” according to Dr. David Berglund, a co-author of the study and a principal investigator in transplant immunology at Uppsala University.

The study can be found in Cytotherapy (, September 2014, Vol. 16, No.

About Cytonome

Cytonome, headquartered in Boston, Massachusetts, has developed the high-speed Gigasort™ cell purification system for use in cell sorting applications where high throughput, sterility and containment are required. Cytonome’s Gigasort™ platform combines a high throughput cell sorting system with a fully-enclosed, sterilized, single-use disposable cartridge. The product is currently available through the Cytonome Early Access Program (“EAP”).